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Why does clubbing occurs in liver cirrhosis?In: Human Anatomy [Recategorize] |
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Even though clubbing is a widely recognized symptom of many diseases the physiological mechanism that actually causes clubbing is not well understood. Current understanding is that these diseases cause http://www.answers.com/topic/vasodilator in the distal circulation which leads to http://www.answers.com/topic/organ-hypertrophy of the tissue of the nailbeds and thus to the clubbed fingernails.
Other factors that have been implicated are the local effects of growth factors (such as http://www.answers.com/topic/platelet-derived-growth-factor and http://www.answers.com/topic/hepatocyte-growth-factor) that are usually sequestrated in the pulmonary capillary bed. Many of the conditions associated with
clubbing result in shunting across some of the capillary beds in the pulmonary circulation.
http://www.answers.com/clubbing
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First answer by Ilantoren. Last edit by Ilantoren. Contributor trust: 203 [recommend contributor]. Question popularity: 31 [recommend question]
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